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PSNPA Dinner Program: Autosomal Dominant Polycystic Kidney Disease

El Gaucho - Grill Room
2505 1st Avenue
Seattle, WA 98121

Tuesday, October 30, 2018 at 6:00pm PT - 8:30pm PT
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2505 1st Avenue, Seattle, WA 98121

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Topic

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Speaker(s)

Laura Frank, PhD, MPH, RD, CD

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Additional Information

Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent, potentially lethal, monogenic human disorder. It is associated with large interfamilial and interfamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. It is also the most common of the inherited cystic kidney diseases — a group of disorders with related but distinct pathogenesis, characterized by the development of renal cysts and various extra-renal manifestations, which in case of ADPKD include cysts in other organs, such as the liverseminal vesiclespancreas, and arachnoid membrane, as well as other abnormalities, such as intracranial aneurysms and dolichoectasiasaortic root dilatation and aneurysms, mitral valve prolapse, and abdominal wall hernias. Over 50% of patients with ADPKD eventually develop end stage kidney disease and require dialysis or kidney transplantation. ADPKD is estimated to affect at least 1 in every 1000 individuals worldwide, making this disease the most common inherited kidney disorder with a diagnosed prevalence of 1:2000 and incidence of 1:3000-1:8000 in a global scale

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